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A PAI-1 Mutant, PAI-1R, Slows Progression of Diabetic Nephropathy
Plasminogen activator inhibitor-1 (PAI-1) has been implicated in renal fibrosis. In vitro, PAI-1 inhibits plasmin generation, and this decreases mesangial extracellular matrix turnover. PAI-1R, a mutant PAI-1, increases glomerular plasmin generation, reverses PAI-1 inhibition of matrix degradation,...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396741/ https://ncbi.nlm.nih.gov/pubmed/18216319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040510 |
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