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The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

BACKGROUND: Recent animal and human studies implicate chronic activation of microglia in the progressive loss of CNS neurons. The inflammatory mechanisms that have neurotoxic effects and contribute to neurodegeneration need to be elucidated and specifically targeted without interfering with the neur...

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Detalhes bibliográficos
Main Authors: Tran, Thi A, McCoy, Melissa K, Sporn, Michael B, Tansey, Malú G
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396606/
https://ncbi.nlm.nih.gov/pubmed/18474101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-5-14
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