C3H/HeN mouse model for the evaluation of antiviral agents for the treatment of Venezuelan equine encephalitis virus infection

The TC-83 vaccine strain of Venezuelan equine encephalitis virus (VEEV) causes encephalitis and death in C3H/HeN mice infected by intranasal instillation. Since TC-83 is exempt as a Select Agent, this mouse model was used in the evaluation of antiviral therapies. Virus titers in the brains of infect...

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Main Authors: Julander, Justin G., Skirpstunas, Ramona, Siddharthan, Venkatraman, Shafer, Kristiina, Hoopes, Justin D., Smee, Donald F., Morrey, John D.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396595/
https://ncbi.nlm.nih.gov/pubmed/18313150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.antiviral.2008.01.007
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