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Withdrawal from cocaine self-administration produces long-lasting deficits in orbitofrontal-dependent reversal learning in rats

Drug addicts make poor decisions. These decision-making deficits have been modeled in addicts and laboratory animals using reversal-learning tasks. However, persistent reversal-learning impairments have been shown in rats and monkeys only after noncontingent cocaine injections. Current thinking hold...

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Detalhes bibliográficos
Main Authors: Calu, Donna J., Stalnaker, Thomas A., Franz, Theresa M., Singh, Teghpal, Shaham, Yavin, Schoenbaum, Geoffrey
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396594/
https://ncbi.nlm.nih.gov/pubmed/17522022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/lm.534807
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