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Intra-endodermal interactions are required for pancreatic β-cell induction

The cellular origin of signals that regulate pancreatic β-cell induction is not clearly defined. Here, we investigate the seeming paradox that Hedgehog/Smoothened signaling functions during gastrulation to promote pancreatic β-cell development in zebrafish, yet has an inhibitory role during later st...

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Bibliographic Details
Main Authors: Chung, Won-Suk, Stainier, Didier Y. R.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396532/
https://ncbi.nlm.nih.gov/pubmed/18410733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2008.02.012
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