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Analysis of the DNA Binding Activity of BRCA1 and Its Modulation by the Tumour Suppressor p53
BACKGROUND: The breast cancer susceptibility protein, BRCA1 functions to maintain the integrity of the genome. The exact mechanisms by which it does so, however, remain unclear. The ability of BRCA1 to bind directly to DNA suggests a more direct role. However, little research has been conducted to u...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2008
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396507/ https://ncbi.nlm.nih.gov/pubmed/18545657 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0002336 |
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