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RNAi-mediated Downregulation of Urokinase Plasminogen Activator Receptor (uPAR) and Matrix Metalloprotease-9 (MMP-9) in Human Breast Cancer Cells Results in Decreased Tumor Invasion, Angiogenesis and Growth

The serine protease urokinase-type plasminogen activator (uPA) plays a significant role in tumor cell invasion and metastasis when bound to its specific receptor, uPAR (also known as CD87). In addition to the uPA-uPAR system, matrix metalloproteinases (MMPs) are involved in tumor cell invasion and m...

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Bibliografiske detaljer
Main Authors: Kunigal, Sateesh, Lakka, Sajani S., Gondi, Christopher S., Estes, Norman, Rao, Jasti S.
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396459/
https://ncbi.nlm.nih.gov/pubmed/17657740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.22962
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