Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)

Understanding how DNA polymerases control fidelity requires elucidation of the mechanisms of matched and mismatched dNTP incorporations. Little is known about the latter because mismatched complexes do not crystallize readily. In this report, we employed small-angle X-ray scattering (SAXS) and struc...

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Detalles Bibliográficos
Main Authors: Tang, Kuo-Hsiang, Niebuhr, Marc, Tung, Chang-Shung, Chan, Hsiu-chien, Chou, Chia-Cheng, Tsai, Ming-Daw
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
Assuntos:
Structural Biology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396427/
https://ncbi.nlm.nih.gov/pubmed/18385153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn138
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