Mismatched dNTP incorporation by DNA polymerase β does not proceed via globally different conformational pathways(†)

Understanding how DNA polymerases control fidelity requires elucidation of the mechanisms of matched and mismatched dNTP incorporations. Little is known about the latter because mismatched complexes do not crystallize readily. In this report, we employed small-angle X-ray scattering (SAXS) and struc...

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Hlavní autoři: Tang, Kuo-Hsiang, Niebuhr, Marc, Tung, Chang-Shung, Chan, Hsiu-chien, Chou, Chia-Cheng, Tsai, Ming-Daw
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2008
Témata:
Structural Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396427/
https://ncbi.nlm.nih.gov/pubmed/18385153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkn138
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