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Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3
The human Mediator complex is generally required for expression of protein-coding genes. Here, we show that the GCN5L acetyltransferase stably associates with Mediator together with the TRRAP polypeptide. Yet, contrary to expectations, TRRAP/GCN5L does not associate with the transcriptionally active...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Nature Publishing Group
2008
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2396395/ https://ncbi.nlm.nih.gov/pubmed/18418385 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2008.78 |
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