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Mechanism-Based Model of the Pharmacokinetics of Enfuvirtide, an HIV Fusion Inhibitor

We present a model of the pharmacokinetics of enfuvirtide, a potent inhibitor of the fusion of human immunodeficiency virus type 1 (HIV-1) with target cells. We assume that subcutaneously administered enfuvirtide accumulates in the injection region, diffuses locally, and gets absorbed into blood, wh...

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Autors principals: Mohanty, Utkala, Dixit, Narendra M.
Format: Artigo
Idioma:Inglês
Publicat: 2007
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396229/
https://ncbi.nlm.nih.gov/pubmed/18258267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2007.12.017
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