A luteinizing hormone receptor intronic variant is significantly associated with decreased risk of Alzheimer's disease in males carrying an apolipoprotein E ε4 allele

Genetic and biochemical studies support the apolipoprotein E (APOE) ε4 allele as a major risk factor for late-onset Alzheimer's disease (AD), though ~50% of AD patients do not carry the allele. APOE transports cholesterol for luteinizing hormone (LH)-regulated steroidogenesis, and both LH and n...

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Detalhes bibliográficos
Main Authors: Haasl, Ryan J, Ahmadi, M Reza, Meethal, Sivan Vadakkadath, Gleason, Carey E, Johnson, Sterling C, Asthana, Sanjay, Bowen, Richard L, Atwood, Craig S
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2396156/
https://ncbi.nlm.nih.gov/pubmed/18439297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2350-9-37
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