Contribution of CD8(+) T Cells to Containment of Viral Replication and Emergence of Mutations in Mamu-A*01-Restricted Epitopes in Simian Immunodeficiency Virus-Infected Rhesus Monkeys

Here, we investigated the containment of virus replication in simian immunodeficiency virus (SIV) infection by CD8(+) lymphocytes. Escape mutations in Mamu-A*01 epitopes appeared first in SIV Tat TL8 and then in SIV Gag p11C. The appearance of escape mutations in SIV Gag p11C was coincident with com...

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Detalhes bibliográficos
Main Authors: Kim, Eun-Young, Veazey, Ronald S., Zahn, Roland, McEvers, Kimberly J., Baumeister, Susanne H. C., Foster, Gabriel J., Rett, Melisa D., Newberg, Michael H., Kuroda, Marcelo J., Rieber, E. Peter, Piatak, Michael, Lifson, Jeffrey D., Letvin, Norman L., Wolinsky, Steven M., Schmitz, Jörn E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395222/
https://ncbi.nlm.nih.gov/pubmed/18367519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02749-07
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