Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly

Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are the specific targets of these drugs. Furthermore, one can isolate drug-resistant virus carrying mutations in the viral DNA ligase and yet the ligase is not k...

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Detalhes bibliográficos
Main Authors: Lin, Y.-C. James, Li, Jianhong, Irwin, Chad R., Jenkins, Heather, DeLange, Luke, Evans, David H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395158/
https://ncbi.nlm.nih.gov/pubmed/18417590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02723-07
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