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Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly

Vaccinia virus replication is inhibited by etoposide and mitoxantrone even though poxviruses do not encode the type II topoisomerases that are the specific targets of these drugs. Furthermore, one can isolate drug-resistant virus carrying mutations in the viral DNA ligase and yet the ligase is not k...

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Bibliografske podrobnosti
Main Authors:	Lin, Y.-C. James, Li, Jianhong, Irwin, Chad R., Jenkins, Heather, DeLange, Luke, Evans, David H.
Format:	Artigo
Jezik:	Inglês
Izdano:	American Society for Microbiology (ASM) 2008
Teme:	Genome Replication and Regulation of Viral Gene Expression
Online dostop:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2395158/ https://ncbi.nlm.nih.gov/pubmed/18417590 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02723-07
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Vaccinia Virus DNA Ligase Recruits Cellular Topoisomerase II to Sites of Viral Replication and Assembly

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