Kaposi's Sarcoma-Associated Herpesvirus-Encoded LANA Recruits Topoisomerase IIβ for Latent DNA Replication of the Terminal Repeats

The latency-associated nuclear antigen (LANA) encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) plays a major role in maintaining latency and is critical for the perpetual segregation of viral episomes to the progeny nuclei of newly divided cells. LANA binds to KSHV terminal repeat (TR)...

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Detalhes bibliográficos
Main Authors: Purushothaman, Pravinkumar, McDowell, Maria E., McGuinness, James, Salas, Ruth, Rumjahn, Sharif M., Verma, Subhash C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3446556/
https://ncbi.nlm.nih.gov/pubmed/22761383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00839-12
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