Definition of a Conserved Immunodominant Domain on Hepatitis C Virus E2 Glycoprotein by Neutralizing Human Monoclonal Antibodies

Development of a successful hepatitis C virus (HCV) vaccine requires the definition of neutralization epitopes that are conserved among different HCV genotypes. Five human monoclonal antibodies (HMAbs) are described that cross-compete with other antibodies to a cluster of overlapping epitopes, previ...

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Bibliografiske detaljer
Main Authors: Keck, Zhen-Yong, Li, Ta-Kai, Xia, Jinming, Gal-Tanamy, Meital, Olson, Oakley, Li, Sophia H., Patel, Arvind H., Ball, Jonathan K., Lemon, Stanley M., Foung, Steven K. H.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Pathogenesis and Immunity
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395155/
https://ncbi.nlm.nih.gov/pubmed/18400849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02475-07
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