A Point Mutation Leading to Hepatitis C Virus Escape from Neutralization by a Monoclonal Antibody to a Conserved Conformational Epitope

A challenge in hepatitis C virus (HCV) vaccine development is defining conserved protective epitopes. A cluster of these epitopes comprises an immunodominant domain on the E2 glycoprotein, designated domain B. CBH-2 is a neutralizing human monoclonal antibody to a domain B epitope that is highly con...

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Hlavní autoři: Keck, Zhen-Yong, Olson, Oakley, Gal-Tanamy, Meital, Xia, Jinming, Patel, Arvind H., Dreux, Marlène, Cosset, Francois-Loïc, Lemon, Stanley M., Foung, Steven K. H.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2008
Témata:
Pathogenesis and Immunity
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2395135/
https://ncbi.nlm.nih.gov/pubmed/18385242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00252-08
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