Malic Acid Production by Saccharomyces cerevisiae: Engineering of Pyruvate Carboxylation, Oxaloacetate Reduction, and Malate Export

Malic acid is a potential biomass-derivable “building block” for chemical synthesis. Since wild-type Saccharomyces cerevisiae strains produce only low levels of malate, metabolic engineering is required to achieve efficient malate production with this yeast. A promising pathway for malate production...

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Hauptverfasser: Zelle, Rintze M., de Hulster, Erik, van Winden, Wouter A., de Waard, Pieter, Dijkema, Cor, Winkler, Aaron A., Geertman, Jan-Maarten A., van Dijken, Johannes P., Pronk, Jack T., van Maris, Antonius J. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Physiology and Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394876/
https://ncbi.nlm.nih.gov/pubmed/18344340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02591-07
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