Phase I Dose-Escalation Study of a Monovalent Heat Shock Protein 70-Herpes Simplex Virus Type 2 (HSV-2) Peptide-Based Vaccine Designed To Prime or Boost CD8 T-Cell Responses in HSV-Naïve and HSV-2-Infected Subjects

This was a phase I study to assess the safety, tolerability, and immunogenicity of escalating doses of AG-702, a noncovalent complex of an HLA A*0201-restricted epitope in the glycoprotein B protein of herpes simplex virus type 2 (gB2) and truncated human constitutive heat shock protein 70. Similar...

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Bibliografske podrobnosti
Main Authors: Koelle, David M., Magaret, Amalia, McClurkan, Christopher L., Remington, Michael L., Warren, Terri, Teofilovici, Florentina, Wald, Anna
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Vaccine Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394846/
https://ncbi.nlm.nih.gov/pubmed/18353920
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00020-08
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