Repeated methamphetamine causes long-lasting presynaptic corticostriatal depression that is renormalized with drug readministration

Addiction-associated behaviors such as drug craving and relapse are hypothesized to result from synaptic changes that persist long after withdrawal that are renormalized by drug reinstatement, although such chronic synaptic effects have not been identified. We report that exposure to the dopamine re...

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Main Authors: Bamford, Nigel S., Zhang, Hui, Joyce, John A., Scarlis, Christine A., Hanan, Whitney, Wu, Nan-Ping, André, Véronique M., Cohen, Rachel, Cepeda, Carlos, Levine, Michael S., Harleton, Erin, Sulzer, David
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394729/
https://ncbi.nlm.nih.gov/pubmed/18400166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2008.01.033
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