CD40-targeted adenoviral GM-CSF gene transfer enhances and prolongs the maturation of human CML-derived dendritic cells upon cytokine deprivation

Vaccination with autologous leukaemia-derived dendritic cells (DC) presents an adjuvant treatment option for chronic myeloid leukaemia (CML). Here, we show that high-efficiency CD40-targeted adenoviral gene transfer of GM-CSF to CML-derived DC induces long-lived maturation in the absence of exogenou...

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Sonraí Bibleagrafaíochta
Main Authors: Stam, A G M, Santegoets, S J A M, Westers, T M, Sombroek, C C, Janssen, J J W M, Tillman, B W, Loosdrecht, A A van de, Pinedo, H M, Curiel, D T, Ossenkoppele, G J, Scheper, R J, de Gruijl, T D
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group 2003
Ábhair:
Short Communication
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394320/
https://ncbi.nlm.nih.gov/pubmed/14520439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601225
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