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Microvascular mechanisms by which the combretastatin A-4 derivative AC7700 (AVE8062) induces tumour blood flow stasis

We previously reported that a novel combretastatin A-4 derivative, AC7700, has remarkable antitumour effects because of an irreversible stasis of tumour blood flow (TBF) and subsequent loss of nutrient supply to tumour tissue. Since early 2002, under the new designation AVE8062, AC7700 has undergone...

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Detalhes bibliográficos
Main Authors: Hori, K, Saito, S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2394288/
https://ncbi.nlm.nih.gov/pubmed/14520469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601261
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