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Advantages of a single-cycle production assay to study cell culture-adaptive mutations of hepatitis C virus
The JFH1 strain of hepatitis C virus (HCV) is unique among HCV isolates, in that the wild-type virus can traverse the entire replication cycle in cultured cells. However, without adaptive mutations, only low levels of infectious virus are produced. In the present study, the effects of five mutations...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2008
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2393785/ https://ncbi.nlm.nih.gov/pubmed/18334634 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0800422105 |
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