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Confinement of caspase-12 proteolytic activity to autoprocessing
Caspase-12 is a dominant-negative regulator of caspase-1 (IL-1β-converting enzyme) and an attenuator of cytokine responsiveness to septic infections. This molecular role for caspase-12 appears to be akin to the role of cFLIP in regulating caspase-8 in the extrinsic cell death pathway; however, unlik...
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| Hauptverfasser: | , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2393782/ https://ncbi.nlm.nih.gov/pubmed/18332441 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0706658105 |
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