Sirolimus Reduces Polycystic Liver Volume in ADPKD Patients

The immunosuppressive agent sirolimus exerts an antiproliferative effect by inhibiting mammalian target of rapamycin (mTOR). Because excessive proliferation of the biliary epithelium is a prominent feature of the polycystic liver that accompanies autosomal dominant polycystic kidney disease (ADPKD),...

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Main Authors: Qian, Qi, Du, Hui, King, Bernard F., Kumar, Sumedha, Dean, Patrick G., Cosio, Fernando G., Torres, Vicente E.
格式: Artigo
語言:Inglês
出版: American Society of Nephrology 2008
主題:
Clinical Research
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391057/
https://ncbi.nlm.nih.gov/pubmed/18199797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007050626
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