Sirolimus Reduces Polycystic Liver Volume in ADPKD Patients

The immunosuppressive agent sirolimus exerts an antiproliferative effect by inhibiting mammalian target of rapamycin (mTOR). Because excessive proliferation of the biliary epithelium is a prominent feature of the polycystic liver that accompanies autosomal dominant polycystic kidney disease (ADPKD),...

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Bibliografiska uppgifter
Huvudupphovsmän: Qian, Qi, Du, Hui, King, Bernard F., Kumar, Sumedha, Dean, Patrick G., Cosio, Fernando G., Torres, Vicente E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society of Nephrology 2008
Ämnen:
Clinical Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391057/
https://ncbi.nlm.nih.gov/pubmed/18199797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007050626
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