A Switch in the Mechanism of Hypertension in the Syndrome of Apparent Mineralocorticoid Excess

The syndrome of apparent mineralocorticoid excess arises from nonfunctional mutations in 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2), an enzyme that inactivates cortisol and confers aldosterone specificity on the mineralocorticoid receptor. Loss of 11βHSD2 permits glucocorticoids to activate t...

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Detalhes bibliográficos
Main Authors: Bailey, Matthew A., Paterson, Janice M., Hadoke, Patrick W.F., Wrobel, Nicola, Bellamy, Christopher O.C., Brownstein, David G., Seckl, Jonathan R., Mullins, John J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2008
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2391031/
https://ncbi.nlm.nih.gov/pubmed/18032795
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2007040401
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