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Small Interfering RNA (siRNA)-Directed Reversal of uPA Demethylation Inhibits Prostate Tumor Growth and Metastasis
Recent studies have shown that siRNA silence genes at the transcriptional level in human cells. However, the therapeutic potential of siRNA-mediated transcriptional gene silencing remains unclear. Here, we show that siRNA targeted to the uPA promoter induced epigenetic transcriptional silencing in h...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2007
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390768/ https://ncbi.nlm.nih.gov/pubmed/17638874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-07-0751 |
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