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RNA-Based 5-Fluorouracil Toxicity Requires the Pseudouridylation Activity of Cbf5p
The chemotherapeutic drug 5-fluorouracil (5FU) disrupts DNA synthesis by inhibiting the enzymatic conversion of dUMP to dTMP. However, mounting evidence indicates that 5FU has important effects on RNA metabolism that contribute significantly to the toxicity of the drug. Strains with mutations in nuc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2390612/ https://ncbi.nlm.nih.gov/pubmed/18493057 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.082727 |
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