Rational engineering of a miniprotein that reproduces the core of the CD4 site interacting with HIV-1 envelope glycoprotein

Protein–protein interacting surfaces are usually large and intricate, making the rational design of small mimetics of these interfaces a daunting problem. On the basis of a structural similarity between the CDR2-like loop of CD4 and the β-hairpin region of a short scorpion toxin, scyllatoxin, we tra...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Vita, Claudio, Drakopoulou, Eugenia, Vizzavona, Jean, Rochette, Sandrine, Martin, Loïc, Ménez, André, Roumestand, Christian, Yang, Yin-Shan, Ylisastigui, Loyda, Benjouad, Abdelaziz, Gluckman, Jean Claude
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23905/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10557278/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.23.13091
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