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Trispecific eFab-eIg T-cell engagers targeting HER2 and HER3

Trispecific antibodies have emerged as molecules for enhanced cancer immunotherapy by addressing the complexity of cancer cell biology and anti-cancer immune responses. Here, we present a novel approach to generate trispecific antibodies based on the previously developed eIg technology. These trispe...

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Autori principali: Ann-Kathrin Löffler, Annika Huber, Monilola A. Olayioye, Roland E. Kontermann, Oliver Seifert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2025-08-01
Serie:Frontiers in Immunology
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Accesso online:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1642454/full
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