Treatment of Radioresistant Stem-Like Esophageal Cancer Cells by an Apoptotic Gene–Armed, Telomerase-Specific Oncolytic Adenovirus

PURPOSE: Radioresistance may be caused by cancer stem cells (CSCs). Because CSCs require telomerase to proliferate, a telomerase-specific oncolytic adenoviral vector carrying apoptotic TRAIL and E1A gene (Ad/TRAIL-E1) may preferentially target CSCs. EXPERIMENTAL DESIGN: We established two pairs of p...

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Hlavní autoři: Zhang, Xiaochun, Komaki, Ritsuko, Wang, Li, Fang, Bingliang, Chang, Joe Y.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2387204/
https://ncbi.nlm.nih.gov/pubmed/18451249
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1528
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