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Treatment of Radioresistant Stem-Like Esophageal Cancer Cells by an Apoptotic Gene–Armed, Telomerase-Specific Oncolytic Adenovirus
PURPOSE: Radioresistance may be caused by cancer stem cells (CSCs). Because CSCs require telomerase to proliferate, a telomerase-specific oncolytic adenoviral vector carrying apoptotic TRAIL and E1A gene (Ad/TRAIL-E1) may preferentially target CSCs. EXPERIMENTAL DESIGN: We established two pairs of p...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2387204/ https://ncbi.nlm.nih.gov/pubmed/18451249 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-07-1528 |
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