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A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong CTLA-4 gene association
AIMS/HYPOTHESIS: HLA haplotypes DRB1*03-DQB1*02 and DRB1*04-DQB1*0302, allelic variation of the T cell regulatory gene CTLA4 and allelic variation of the T cell activation gene PTPN22, have been associated with type 1 diabetes and autoimmune thyroid disease (AITD). Using thyroid peroxidase autoantib...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2387192/ https://ncbi.nlm.nih.gov/pubmed/17334650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-007-0603-6 |
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