Quantitative correlation between promoter methylation and messenger RNA levels of the reduced folate carrier

BACKGROUND: Methotrexate (MTX) uptake is mediated by the reduced folate carrier (RFC). Defective drug uptake in association with decreased RFC expression is a common mechanism of MTX resistance in many tumor types. Heavy promoter methylation was previously identified as a basis for the complete sile...

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Main Authors: Yang, Rui, Li, Wei-Wei, Hoang, Bang H, Kim, Hansoo, Banerjee, Debabrata, Kheradpour, Albert, Healey, John H, Meyers, Paul A, Bertino, Joseph R, Gorlick, Richard
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2008
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2387170/
https://ncbi.nlm.nih.gov/pubmed/18452618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-8-124
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