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Activation of Syk by Protein Kinase C-δ Regulates Thrombin-induced Intercellular Adhesion Molecule-1 Expression in Endothelial Cells via Tyrosine Phosphorylation of RelA/p65

Protein kinase C-δ (PKC-δ) plays a pivotal role in mediating thrombin-induced NF-κB activation and ICAM-1 expression in endothelial cells. However, the downstream mechanisms mediating its function are unclear. In this study, we show that PKC-δ-mediated activation of protein-tyrosine kinase Syk plays...

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Main Authors: Bijli, Kaiser M., Fazal, Fabeha, Minhajuddin, Mohd, Rahman, Arshad
格式: Artigo
語言:Inglês
出版: American Society for Biochemistry and Molecular Biology 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386948/
https://ncbi.nlm.nih.gov/pubmed/18362147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M802094200
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