Impaired Bcl3 Up-regulation Leads to Enhanced Lipopolysaccharide-induced Interleukin (IL)-23P19 Gene Expression in IL-10(–/–) Mice

Genetic and biochemical analyses show that IL-23p19 plays a central role in mediating bacteria-induced colitis in interleukin-10-deficient (IL-10(–/–)) mice. The molecular mechanisms responsible for the dysregulated innate host response leading to enhanced IL-23 gene expression in IL-10(–/–) mice ar...

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Библиографические подробности
Главные авторы: Mühlbauer, Marcus, Chilton, Paula M., Mitchell, Thomas C., Jobin, Christian
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2008
Предметы:
Mechanisms of Signal Transduction
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386919/
https://ncbi.nlm.nih.gov/pubmed/18375954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M709029200
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