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Diverse metabolic model parameters generate similar methionine cycle dynamics

Parameter estimation constitutes a major challenge in dynamic modeling of metabolic networks. Here we examine, via computational simulations, the influence of system nonlinearity and the nature of available data on the distribution and predictive capability of identified model parameters. Simulated...

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Bibliografske podrobnosti
Main Authors: Piazza, Matthew, Feng, Xiao-Jiang, Rabinowitz, Joshua D., Rabitz, Herschel
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386584/
https://ncbi.nlm.nih.gov/pubmed/18313076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jtbi.2007.12.009
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