Chloroquine and inhibition of Toll-like receptor 9 protect from sepsis-induced acute kidney injury

Mortality from sepsis has remained high despite recent advances in supportive and targeted therapies. Toll-like receptors (TLRs) sense bacterial products and stimulate pathogenic innate immune responses. Mice deficient in the common adapter protein MyD88, downstream from most TLRs, have reduced mort...

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Detalhes bibliográficos
Main Authors: Yasuda, Hideo, Leelahavanichkul, Asada, Tsunoda, Shinichiro, Dear, James W., Takahashi, Yoshiyuki, Ito, Shuichi, Hu, Xuzhen, Zhou, Hua, Doi, Kent, Childs, Richard, Klinman, Dennis M., Yuen, Peter S.T., Star, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386262/
https://ncbi.nlm.nih.gov/pubmed/18305095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00461.2007
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