Myofiber integrity depends on desmin network targeting to Z-disks and costameres via distinct plectin isoforms

Dysfunction of plectin, a 500-kD cytolinker protein, leads to skin blistering and muscular dystrophy. Using conditional gene targeting in mice, we show that plectin deficiency results in progressive degenerative alterations in striated muscle, including aggregation and partial loss of intermediate f...

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Detalhes bibliográficos
Main Authors: Konieczny, Patryk, Fuchs, Peter, Reipert, Siegfried, Kunz, Wolfram S., Zeöld, Anikó, Fischer, Irmgard, Paulin, Denise, Schröder, Rolf, Wiche, Gerhard
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2008
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2386106/
https://ncbi.nlm.nih.gov/pubmed/18490514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711058
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