Polyomavirus large and small T antigens cooperate in induction of the S phase in serum-starved 3T3 mouse fibroblasts.

Eitemau Tebyg

• Coordinated trans activation of DNA synthesis- and precursor-producing enzymes by polyomavirus large T antigen through interaction with the retinoblastoma protein.
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• Binding of Polyomavirus Small T Antigen to Protein Phosphatase 2A Is Required for Elimination of p27 and Support of S-Phase Induction in Concert with Large T Antigen
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  Cyhoeddwyd: (1999)
• Polyomavirus small T antigen enhances replication of viral genomes in 3T6 mouse fibroblasts.
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• A binding site for transcription factor E2F is a target for trans activation of murine thymidine kinase by polyomavirus large T antigen and plays an important role in growth regulation of the gene.
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  Cyhoeddwyd: (1993)
• Polyomavirus Large T Antigen Binds the Transcriptional Coactivator Protein p300
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  Cyhoeddwyd: (1999)