Slow dimer dissociation of the TATA binding protein dictates the kinetics of DNA binding
The association of the TATA binding protein (TBP) to eukaryotic promoters is a possible rate-limiting step in gene expression. Slow promoter binding might be related to TBP’s ability to occlude its DNA binding domain through dimerization. Using a “pull-down” based assay, we find that TBP dimers diss...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Principais autores: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23798/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207072/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7221 |
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