Detection of residue contacts in a protein folding intermediate

Protein folding can be described in terms of the development of specific contacts between residues as a highly disordered polypeptide chain converts into the native state. Here we describe an NMR based strategy designed to detect such contacts by observation of nuclear Overhauser effects (NOEs). Exp...

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Main Authors: Balbach, Jochen, Forge, Vincent, Lau, Wai Shun, Jones, Jonathan A., van Nuland, Nico A. J., Dobson, Christopher M.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences of the USA 1997
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23785/
https://ncbi.nlm.nih.gov/pubmed/9207065
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