Viral determinants that control the neuropathogenicity of PVC-211 murine leukemia virus in vivo determine brain capillary endothelial cell tropism of the virus in vitro.

PVC-211 murine leukemia virus (MuLV) is a neuropathogenic, weakly leukemogenic variant of the nonneuropathogenic, highly leukemogenic Friend MuLV (F-MuLV). Chimeric viruses constructed from PVC-211 MuLV clone 3d and F-MuLV clone 57 indicate that the env gene of PVC-211 MuLV contains the determinant(...

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Main Authors: Masuda, M, Hoffman, P M, Ruscetti, S K
Formato: Artigo
Idioma:Inglês
Publicado em: 1993
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC237842/
https://ncbi.nlm.nih.gov/pubmed/8392599
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