The E5 oncoprotein of human papillomavirus type 16 transforms fibroblasts and effects the downregulation of the epidermal growth factor receptor in keratinocytes.

To determine the function of the E5 open reading frame (ORF) of the human papillomaviruses (HPVs), rodent fibroblast cell lines were transfected with the E5 ORF of HPV type 6 (HPV-6) and HPV-16 expressed from an exogenous promoter. Transfected fibroblasts were transformed to colony formation in soft...

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Detalhes bibliográficos

Publicado no:	J Virol
Principais autores:	Straight, S W, Hinkle, P M, Jewers, R J, McCance, D J
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC237836/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8392596/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jvi.67.8.4521-4532.1993
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