X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase

To be effective as antiviral agent, AZT (3′-azido-3′-deoxythymidine) must be converted to a triphosphate derivative by cellular kinases. The conversion is inefficient and, to understand why AZT diphosphate is a poor substrate of nucleoside diphosphate (NDP) kinase, we determined a 2.3-Å x-ray struct...

ver descrição completa

Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Xu, Yingwu, Sellam, Olivier, Moréra, Solange, Sarfati, Simon, Biondi, Ricardo, Véron, Michel, Janin, Joël
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1997
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC23778/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9207061/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.94.14.7162
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!