X-ray analysis of azido-thymidine diphosphate binding to nucleoside diphosphate kinase

To be effective as antiviral agent, AZT (3′-azido-3′-deoxythymidine) must be converted to a triphosphate derivative by cellular kinases. The conversion is inefficient and, to understand why AZT diphosphate is a poor substrate of nucleoside diphosphate (NDP) kinase, we determined a 2.3-Å x-ray struct...

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Bibliographische Detailangaben
Hauptverfasser: Xu, Yingwu, Sellam, Olivier, Moréra, Solange, Sarfati, Simon, Biondi, Ricardo, Véron, Michel, Janin, Joël
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences of the USA 1997
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC23778/
https://ncbi.nlm.nih.gov/pubmed/9207061
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