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Prokaryotic BirA ligase biotinylates K4, K9, K18 and K23 in histone H3

BirA ligase, a prokaryotic ortholog of holocarboxylase synthetase (HCS), is known to biotinylate proteins. Here, we tested the hypothesis that BirA ligase catalyzes biotinylation of eukaryotic histones. If so, this would render recombinant BirA ligase a useful surrogate for HCS in studies of histone...

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Bibliografiske detaljer
Main Authors: Kobza, Keyna, Sarath, Gautam, Zempleni, Janos
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377390/
https://ncbi.nlm.nih.gov/pubmed/18452652
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