Many-trillionfold amplification of single RNA virus particles fails to overcome the Muller's ratchet effect.

We showed earlier that transfers of large populations of RNA viruses lead to fitness gains and that repeated genetic bottleneck transfers result in fitness losses due to Muller's ratchet. In the present study, we examined the effects of genetic bottleneck passages intervening between population...

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Bibliographic Details
Main Authors: Duarte, E A, Clarke, D K, Moya, A, Elena, S F, Domingo, E, Holland, J
Format: Artigo
Language:Inglês
Published: 1993
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC237712/
https://ncbi.nlm.nih.gov/pubmed/8388514
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