Evaluation of clinical significance of TP53, BCL-2, BAX and MEK1 expression in 229 ovarian carcinomas treated with platinum-based regimen

In cell line studies, BCL-2, BAX, as well as novel MEK1 protein levels have strong influence on ovarian cancer response to cisplatin-based chemotherapy. However, such associations have not been demonstrated clinically. We evaluated prognostic/predictive significance of these proteins with regard to...

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Autors principals: Kupryjańczyk, J, Szymańska, T, Mądry, R, Timorek, A, Stelmachów, J, Karpińska, G, Rembiszewska, A, Ziółkowska, I, Kraszewska, E, Dębniak, J, Emerich, J, Ułańska, M, Płużańska, A, Jędryka, M, Goluda, M, Chudecka-Głaz, A, Rzepka-Górska, I, Klimek, M, Urbański, K, Bręborowicz, J, Zieliński, J, Markowska, J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2003
Matèries:
Molecular and Cellular Pathology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2377076/
https://ncbi.nlm.nih.gov/pubmed/12644821
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600789
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