High frequency of mitochondrial genome instability in human endometrial carcinomas

To investigate the occurrence of somatic mitochondrial DNA (mtDNA) mutations in human primary endometrial carcinomas, we sequenced the D-loop region, the 12S and 16S rRNA genes of mtDNA of cancer tissues and their matched normal controls. About 56% (28 out of 50) of cases carry one or more somatic c...

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Detalhes bibliográficos
Main Authors: Liu, V W S, Yang, H J, Wang, Y, Tsang, P C K, Cheung, A N Y, Chiu, P M, Ng, T Y, Wong, L C, Nagley, P, Ngan, H Y S
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2003
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2376924/
https://ncbi.nlm.nih.gov/pubmed/12915881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6601110
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