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p21-activated Kinase-aberrant Activation and Translocation in Alzheimer Disease Pathogenesis
Defects in dendritic spines and synapses contribute to cognitive deficits in mental retardation syndromes and, potentially, Alzheimer disease. p21-activated kinases (PAKs) regulate actin filaments and morphogenesis of dendritic spines regulated by the Rho family GTPases Rac and Cdc42. We previously...
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| Главные авторы: | , , , , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
American Society for Biochemistry and Molecular Biology
2008
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2376243/ https://ncbi.nlm.nih.gov/pubmed/18347024 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M708034200 |
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